Young fibroblast-derived exosomal microRNA-125b transfers beneficial effects on aged cutaneous wound healing
Abstract Aged skin wounds heal poorly, resulting in medical, economic, and social burdens posed by nonhealing wounds.Age-related defects in repair are associated with reduced myofibroblasts and dysfunctional extracellular matrix (ECM) deposition.Bidirectional cell-cell communication involving exosome-borne cargo such as micro RNAs (miRs) has emerge